Which type of synthetic suture is known to be the least reactive in tissue?

Polypropylene is recognized as the least reactive synthetic suture in tissue due to its unique chemical composition and molecular structure. This suture material is made from a long chain of polypropylene polymer, which is a non-absorbable material. Its low tissue reactivity is one of its key advantages, as it does not provoke significant inflammatory responses upon implantation.

The smooth surface of polypropylene allows it to glide through tissue easily, minimizing trauma and irritation. Additionally, since it is not absorbed by the body, it remains intact over time, offering reliable long-term support in various surgical applications. This property makes polypropylene particularly valuable in situations where minimal tissue reaction is crucial, such as in the repair of sensitive structures or when a prolonged presence of the suture is required.

In contrast, other options such as polyglycolic acid, silk, and polyester have varying degrees of tissue reactivity. Polyglycolic acid is absorbable but can elicit a more significant inflammatory response when compared to polypropylene. Silk, a natural suture, tends to provoke a stronger tissue reaction, and polyester, although synthetic, also has higher reactivity due to its braid structure. Therefore, polypropylene remains the premier choice for situations requiring minimal tissue reactivity.