Which condition is known to reduce the shelf life of sterile items?

High temperature is known to reduce the shelf life of sterile items because elevated temperatures can lead to the degradation of packaging materials and the sterilization process itself. The integrity of sterile barriers is compromised in high heat, which can foster the growth of microorganisms if the sterilization is even slightly impaired. The heat can also cause chemical changes in the materials, altering their protective properties and potentially leading to contamination or ineffective sterilization.

In contrast, low humidity typically helps maintain the stability of sterile items, as it prevents moisture-related issues that can lead to microbial growth. Proper ventilation is important for maintaining a sterile environment but does not directly influence the shelf life of items in the same way that temperature does. Minimal handling can reduce the risk of contamination but does not extend the shelf life on its own; rather, it is a practice that supports the maintenance of sterility. Overall, high temperature is the key factor that negatively impacts the longevity and safety of sterile items.