What happens to bone density if osteoclast activity increases significantly?

When osteoclast activity increases significantly, bone density decreases. Osteoclasts are specialized cells that break down bone tissue, a process known as bone resorption. This activity is part of the normal bone remodeling cycle, where old bone is removed to make way for new bone formation by osteoblasts.

If osteoclasts are more active than osteoblasts, the net effect is a loss of bone density, as more bone tissue is being resorbed than is being formed. Over time, this imbalance can lead to conditions such as osteoporosis, where the structural integrity of the bone is compromised, resulting in an increased risk of fractures. Factors that can lead to increased osteoclast activity include hormonal changes, diseases, and certain medications, all of which can contribute to an overall decrease in bone mineral density and strength.